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Fucoidan from laminaria japonica seaweed exerts antitumor effects in breast cancer cells


What can't seaweed do? Another illustration of one of our extracts in Infinimin® and Infiniderm® and their ability to reduce cancer activity. This time in breast cancer cells. More research is needed, but another great step forward.




"Fucoidan is a fucose-rich polysaccharide that has gained attention for its various anticancer properties. However, the effect and underlying mechanism of fucoidan on triple-negative breast cancer (TNBC) are still unknown. In this study, they investigated the anticancer potential of fucoidan from Laminaria japonica. They found that fucoidan showed modest antiproliferative activity against TNBC cells, while it effectively reduced migratory and invasive capacities.


Mechanistically, fucoidan suppressed activation of MAPK and PI3K followed by inhibition of AP-1 and NF-κB signaling in TNBC.


Additionally, fucoidan downregulated expressions of proangiogenic factors in TNBC cells, and fucoidan blocked tumor-elicited tube formation by human umbilical vascular endothelial cells (HUVECs).


We also observed that fucoidan blocked tumor adhesion and invasion towards HUVECs. See figure 5 below of the study that gives a great visual example of the reduction in cancer cells and metastasis.



Surprisingly, fucoidan robustly suppressed tube formation on HUVECs. Moreover, fucoidan inhibited in vivo angiogenesis and micrometastasis in a transgenic zebrafish model. Together, L. japonica fucoidan exhibits potent antitumor effects by its attenuation of invasiveness and proangiogenesis in TNBC.



References


Wen-Jing Hsu, et. al. "Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells." International Journal of Biological Macromolecules. 1/28/20.

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US Patents: 14-454548, 62006732, 89065289, 89078900