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The medicinal mushroom Ganoderma lucidum reduces UV-induced skin cancers



Infinitum Health Advocates,


Another great recent study with our favorite mushroom, Ganoderma Lucidum, found in all of our products. For this study, it's most applying to our Infiniderm® Daily Youth Lotion product.


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As you all know, the medicinal mushroom, Ganoderma lucidum, is traditionally used for treating multiple diseases, including cancer. This study examined skin cancer preventive activity of a commercial product containing spore and fruiting body in 30:8 ratio (GLSF). Extracts of GLSF and spore component (GLS) were prepared using artificial gastrointestinal juice and examined on JB6 cells. GLSF and GLS dose-dependently inhibited epidermal growth factor-induced JB6 transformation at non-toxic concentrations. SKH-1 mice which were fed with diets containing GLSF (1.25%), GLS (0.99%) or the fruiting body (GLF) (0.26%) were exposed to chronic low-dose ultraviolet (UV) radiation to assess their effects on skin carcinogenesis. GLSF, but not GLS or GLF, reduced skin tumor incidence and multiplicity. In non-tumor skin tissues of mice, GLSF attenuated UV-induced epidermal thickening, expression of Ki-67, COX-2 and NF-κB, while in tumor tissues, GLSF increased expression of CD8 and Granzyme B.


To examine the effects of GLSF on UV-induced immunosuppression, mice which were fed with GLSF were evaluated for the contact hypersensitivity (CHS) response to dinitrofluorobenzene (DNFB). GLSF significantly reversed UV-mediated suppression of DNFBinduced CHS by increasing CD8+ and decreasing CD4+ and FoxP3+ T-cells in mouse ears.


Therefore, GLSF prevents skin cancer probably via attenuating UV-induced

immunosuppression.

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If you found the terms in study difficult, educate yourself on some of them. Below is the reference and the full pdf - knowledge is power!


Cheers to your health,


~Infinitum Health Team


Reference


Shahid A, Huang M, Liu M, Shamim MA, Parsa C, Orlando R, et al. (2022) The medicinal mushroom Ganoderma lucidum attenuates UVinduced skin carcinogenesis and

immunosuppression. PLoS ONE 17(3): e0265615


The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and imm
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