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  • Kevin Engholdt

Incarvillateine - the most potent natural pain reliever in the world, yet not an opioid?

Updated: Mar 25

In continuing our discovery and leveraging from our "Out of Many, One Concept" blog for our ReLeaf® pain reliever, we bring another interesting read about our new favorite pain relieving plan, incarvillea sinensis. This time from the world reknown reserach magazine, Nature.


As many of you know from our last blog on this topic, "Out of Many, One", Incarvillea sinensisis a Bignoniaceae plant used to treat rheumatism and relieve pain in traditional Chinese medicine. As a major component of I. sinensis, incarvillateine has shown analgesic activity in mice formalin tests.


For this new study, using a series of animal models, further evaluated the effects of incarvillateine against acute, inflammatory and neuropathic pain. Incarvillateine (10 or 20 mg/kg, i.p.) dose-dependently attenuated acetic acid-induced writhing, but did not affect thermal threshold in the hot plate test. In a Complete Freund’s Adjuvant model, incarvillateine inhibited both thermal hyperalgesia and paw edema and increased interleukin-1β levels.


Additionally, incarvillateine attenuated mechanical allodynia induced by spared nerve injury or paclitaxel, whereas normal mechanical sensation was not affected. Incarvillateine did not affect locomotor activity and time on the rotarod at analgesic doses and no tolerance was observed after 7 consecutive daily doses.





Moreover, incarvillateine-induced antinociception was attenuated by theophylline, 1,3-dipropyl-8-cyclopentylxanthine and 3,7-dimethyl-1-propargylxanthine, but not naloxone, indicating that the effects of incarvillateine on chronic pain were related to the adenosine system, but not opioid system.


These results indicate that incarvillateine is a novel analgesic compound that is effective against inflammatory and neuropathic pain and that its effects are associated with activation of the adenosine system.


Again, just one great ingredient in our new patent pending pain reliever, ReLeaf®


Here's to your pain releaf,


~Infinitum Health Team


References


Wang, M., Yu, G., Yi, S.et al. Antinociceptive effects of incarvillateine, a monoterpene alkaloid fromIncarvillea sinensisand possible involvement of the adenosine system.

Sci Rep5,16107 (2015). https://doi.org/10.1038/srep16107


Finnerup, N. B. et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 14, 162–173 (2015).


Finnerup, N. B., Sindrup, S. H. & Jensen, T. S. The evidence for pharmacological treatment of neuropathic pain. Pain 150, 573–581 (2010).


Zylka, M. J. Pain-relieving prospects for adenosine receptors and ectonucleotidases. Trends Mol. Med. 17,188–196 (2011).




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