Genome-Wide Gene Expression Differences of Lung Cancer Cells modified by Fucoidan from Seaweed
Seaweeds to the rescue ... again!! Another remarkable study on fucoidan, from seaweed, in this case, one of our favorite species, Undaria pinnatifida, available in all of the Infinitum Health products.
Fucoidan has received increasing attention in anti-(lung) tumors. However, the effect of
fucoidan on the gene changes of lung cancer cells (LCCs) has not been examined
systematically. Herein, they investigate the effect of fucoidan on the phenotypes of LCCs
and their gene expression by transcriptome sequencing analysis. The phenotypes of LCCs are significantly inhibited by fucoidan. Importantly, compared to LCCs, 1 mg/ml fucoidan has no effect on the phenotypes of normal cells.
Further, 6,930 differentially expressed genes (DEGs) in the transcriptome of LCCs (3,501 up-regulated and 3,429 down-regulated genes) are detected via RNA-sequencing between the fucoidan and control groups.
GeneOntology analysis confirms that DEGs are reflected in DNA replication, cell-substrate junction, regulation of cell cycle phase transition, apoptosis, focal adhesion, cadherin binding, and cell adhesion molecule binding.
Thus, their findings on the transcriptomic level highlight the therapeutic potential of fucoidan for lung cancer treatment.
Pretty remarkable right? Know that more research is needed, but another great step for research in this field!
Cheers to your health,
~ Infinitum Health Team
Zhao Y, Li X, Zhang H, Yan M, Jia M and Zhou Q (2022) A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan. Frontiers in Bioegineering and Biotechnology 10:844924.
(pdf available for download below)