Synergistic Effect of Maitake Mushroom in combination with Vitamin C in Neuroglioma Cell
Another amazing new study showcasing what we have created with our Infinimin® Immunity Multivitamin!!
Read for more information on how a unique mushroom, Maitake, and Vitamin C have dramatic synergy as anticancer agents in the preclinical setting. More research is needed, but dramatic results!!!
Polysaccharides extracted from the Maitake mushroom (MP) is considered as a potential anticancer agent. The present study was performed to investigate the cytotoxic effects of MP and vitamin C (VC) alone and in combination on the viability of human neuroglioma M059 K cells in vitro. A combination of MP (1.0 mg/mL) and VC (0.4 mmol/L) led to a 53.10% reduction in cell viability and this treatment induced cell cycle arrest at the G2/M phase, and apoptosis occurred in 38.54% of the cells.
Results of Hoechst 33258 staining and Western blot showed apoptotic cells appeared and changes in the expression of apoptosis-related proteins (upregulation of Bax and caspase-3, downregulation of Bcl-2, and activation of poly-(ADP-ribose)-polymerase). More- over, the activities of caspase-3, caspase-8, and caspase-9 were enhanced in M059 K cells.
Figures 2, 3, and 4 have a detailed description showing these dramatic results.
"The inhibiting effect of combined treatment with MP and VC on M059 K cells indicates the mechanism of anticancer activity involved induction of cell apoptosis (cancer cell death)."
As one of the most effective natural compounds for antitumor treatment currently studied in recent years, MP can induce the apoptosis of some human tumor cells. When used in combination with VC, the effect of inducing tumor cell apoptosis is more apparent.
In summary, the combined use of MP and VC has significant antitumor effect and additional studies needed to verify the therapeutic potential of this strategy for treatment of glioblastoma patients.
Pretty impressive results, further validating our extract combination in Infinimin® Immunity Multivitamin!!
1. Duan, et. al. Induction Effect to Apoptosis by MaitakePolysaccharide: Synergistic Effect of ItsCombination With Vitamin C inNeuroglioma Cell. Journal of Evidence-BasedComplementary & Alternative Medicine2017, Vol. 22(4) 667-674.
2. Konno S. Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy. Int J Gen Med. 2009;30:91-108.