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Reishi mushroom has suppressive effect on cervical cancer cell malignancy

One of our lead extracts in Infinimin®, ganoderma lucidum (aka "Reishi" mushroom) does it again, this time with evidence in cervical cancer cells in a unique study from Jinan Hospital.


"The study aimed to explore whether ganoderma lucidum polysaccharide (GLP) exhibits antitumor effect on cervical cancer cells. There were different concentrations of GLP that were used to treat cervical cell. The data from cell counting kit-8 assay proved that the optimal working concentration and time of GLP were 200 µg/mL and treated for 48 hours. The transwell assay demonstrated that GLP could attenuate the invasion and migration abilities of cervical cancer cells. Moreover, flow cytometry illustrated that GLP could promote the apoptosis of cervical cancer cells and limit the cycle of cervical cancer cells (Flow What?). Western blot assay discovered that the expression of pro-apoptosis proteins including Bax, Cleaved Caspases 3 and 9 increased and the antiapoptosis protein Bcl-2 decreased after treated with GLP. Moreover, we found that the expression of E-cadherin was increased, and N-cadherin, Vimentin, and Slug were decreased. Meanwhile, the expression of phosphorylated-JAK and phosphorylated-STAT5 was also decreased in cervical cancer cells treated by GLP, suggesting the inhibitory effect on JAK/STAT5 pathways (see figure 1 for a unique look at the data on this).




All of this data has shown that GLP could alleviate the activity, aggressiveness, block the cell cycle, and promote the apoptosis of cervical cancer cells, which were possible via inhibiting epithelial-mesenchymal and JAK/STAT5 pathways."


References


Hu Jin, et. al. Ganoderma Lucidum Polysaccharide, an Extract from Ganoderma Lucidum, Exerts Suppressive Effect on Cervical Cancer Cell Malignancy through Mitigating Epithelial-Mesenchymal and JAK/ STAT5 Signaling Pathway. Pharmacology. 1/20/2020.

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US Patents: 14-454548, 62006732, 89065289, 89078900